I think the big, game-changing difference is the concept of a fluid canvas. Even before responsive design, this was a massive difference. Much of the best graphic design is built around the marriage between the content and the canvas.
With web/interface design, you have to essentially throw the canvas out the window, and with it goes a whole lot of assumptions we've built up over the years (some dating back to Gutenberg).
It could be argued that the opposite is true and that the canvas is more important than ever. But, in either case, the canvas is no longer the security blanket it once was, and that completely changes everything.
I think the big, game-changing difference is the concept of a fluid canvas. Even before responsive design, this was a massive difference. Much of the best graphic design is built around the marriage between the content and the canvas.
With web/interface design, you have to essentially throw the canvas out the window, and with it goes a whole lot of assumptions we've built up over the years (some dating back to Gutenberg).
It could be argued that the opposite is true and that the canvas is more important than ever. But, in either case, the canvas is no longer the security blanket it once was, and that completely changes everything.